Patients who choose to use Medications for Opioid Use Disorder (MOUD) for opioid addiction have a choice of medications.[1] One type of MOUD involve the use of an “opioid agonist.” An opioid agonist binds to the same receptors in the brain that were activated by the drug of abuse, but in a safer and more controlled manner. These medications can reduce the symptoms of withdrawal and reduce cravings, allowing for a more gradual, controlled recovery process and reducing the risk of relapse. The two opioid agonists used in MOUD are methadone and buprenorphine. Another type of medication called an “opioid antagonist” is a newer form of treatment that will also be discussed. Naltrexone is the only opioid antagonist currently available for treatment.