This module will describe the SBIRT model (Screening, Brief Intervention, Referral to Treatment) for substance use disorders in primary care practice. Given the high prevalence of substance use disorders, among primary care patients, as well as the continuing epidemic of opioid abuse, it is important to provide routine screening for substance use disorders. SBIRT is an evidence-based practice that has shown significant success in varied clinic settings at reducing alcohol and illicit substance use. A description of universal screening practices is provided, including the use of validated, structured screening tools and the components of brief interventions are described. Approved treatments for substance use disorders are discussed, as well as guidelines for when to make treatment referrals.