The epidemics of HIV disease and substance use are mutually-reinforcing, and both involve significant morbidity. People with HIV and SUDs have worse health-related outcomes than those with HIV alone. The webinar will review the epidemiology of HIV and substance use, and address the structural and social factors that affect individual risk, particularly within marginalized communities. We will also discuss substance-HIV interactions at the physiologic level, such as neuroinflammatory changes that may worsen HIV- and addiction-related related cognitive deficits and influence the development of chronic pain syndromes. We will discuss recommended approaches to screening and treatment of HIV and SUDs, including the provision of integrated care, MAT, and evidence-based behavioral interventions.