A randomized clinical trial published in JAMA Internal Medicine found that weekly extended-release buprenorphine during pregnancy was associated with higher rates of abstinence from illicit opioids than daily sublingual buprenorphine among pregnant women with opioid use disorder. Overall maternal and infant outcomes were similar between groups. However, the extended-release buprenorphine group reported fewer serious adverse events, less use of pain medication after delivery, and lower postpartum anxiety scores, supporting its use as a treatment option during pregnancy.
