The goal of these Small Group Discussions is to support interaction among experts and health professionals. In order to facilitate this, the Small Group Discussions are limited to those are part of the mentoring program and no more than ten attendees. Those who are part of the program will receive an email notifying you of an upcoming discussion.

We have generated Frequently Asked Questions from these one-hour discussions. If you are interested in attending one of these Small Group Discussions, join the Mentoring Program!

Below is a recap of some recent Small Group Discussions.

Let’s talk about methadone – The simple critical facts

Eric Ketcham, MD – November 19, 2018

Besides more structured care, how do patients benefit from methadone vs buprenorphine for OUD?

While the structure of daily supervised dosing is important, some patients simply feel better on methadone than buprenorphine. Some patients continue to crave (and use) opioids at even high doses of buprenorphine (e.g. ~32mg/day). Patients with more extensive histories of opioid use (higher doses, longer years, particularly if a longer history of heroin use), may be more successful on methadone than buprenorphine. The most common adverse effects of buprenorphine, for which patients in my clinic seek to transition from bupe to methadone are persistent nausea, and/or a sense of dysphoria.

Is there a special license or certificate required to “prescribe” methadone? Can an NP or PA “prescribe” methadone?

No. Although methadone is a full mu agonist, with multiple medication interactions, and thus has a much narrower therapeutic index than buprenorphine, there is no special training required to “prescribe” methadone. To be specific, any provider with a DEA license can prescribe methadone for pain (which can be very problematic, see discussion below about methadone as an analgesic). However:

  • Methadone for the treatment of opioid use disorder is administered in a specialized, licensed clinic, and is thus “ordered” by the clinician. No special license is required to “order” methadone in such a clinic (but getting the appropriate training/mentoring is highly advisable).
  • A methadone clinic, also known as an Opioid Treatment Program, or “OTP,” (an antiquated title, as referenced in federal statutes), is required to have a physician present for a face-to-face evaluation at the time of induction into methadone treatment (but can, under certain conditions, be performed via telemedicine).
  • After the induction orders are placed, NPs and PAs can order dosing adjustments without the physician present, but the clinic medical director (physician), must co-sign dosing adjustment orders.
Does every patient need a screening EKG before beginning MAT with methadone?

No. It is impractical in the setting of most methadone clinics, and unnecessary to get an EKG at the time of induction for all patients. I refer to the AATOD QTc Interval Screening – Policy and Guidance Statement (2012) guidelines for EKG screening, which AATOD recommends the following for management of cardiac conduction risk in methadone maintained patients:

  1. Consider a baseline and follow-up 12-lead ECG for patients with “a history of arrhythmia, prolonged QTc, a family history of premature death, and/or other significant arrhythmia risk factors” on admission or for suspected arrhythmia risks in ongoing methadone maintained patients.
  2. Referral should be made for cardiac consultation for “known or detected cardiac conditions affecting heart rhythm, unexplained syncope or seizures or a significant increase in QTc from the baseline if known.”
  3. Patients at-risk should be educated on cardiac symptoms to watch for e.g. “racing” heartbeat, dizziness, seizures, or fainting spells and encouraged to contact the clinic” and medical provider and/or emergency services immediately.

AATOD believes that the safeguards outlined above along with individualized induction practices will allow clinicians to optimize safety during methadone treatment. Informed and appropriate clinical monitoring and follow-up will be the best protection for patient safety. Prospective clinical trials are needed before routine ECG screening can be endorsed.’

How do you transition from methadone to buprenorphine? Do patients have to be titrated down to a dose of 30mg first?

This is not well studied, and as discussed in a very thorough review article, by Mannelli, et al (Curr Drug Abuse Rev. 2012 Mar;5(1):52-63), published guidelines are based on small studies, mostly uncontrolled investigations, and mostly on patients on low to moderate methadone doses (60-70mg daily). Furthermore, “due to differences in design and individual variability, a single protocol cannot be formulated.” Unfortunately, approximately “70% of patients receive more than 60 mg per day of methadone in the USA. Lowering the dose of methadone and/or increasing the interval between the last dose of methadone and buprenorphine may be less acceptable in this case, as it exposes patients to relapse.” There is much less data on transitioning patients at higher doses. That said, I have transitioned many patients from methadone to buprenorphine, including several patients at higher doses of methadone, for a variety of reasons. [Although more often I transition patients from bupe to methadone], By far the most common reasons for switching a patient form higher dose methadone to bupe was due to an upcoming move to an area where there was no methadone program; change in insurance status (transitioning from Medicaid to Medicare, or from Medicaid to a commercial payer); or adverse effects of decreased libido, excessive weight gain, or somnolence. [The vast majority of patients on methadone tolerate it well]. These are my overall observations and suggestions:

  • Methadone is a very good medicine for treating OUD, with a longer track record than buprenorphine, and overall higher rates of patient retention than buprenorphine.
  • Due to logistics, and/or patient preference/tolerance, and sometimes for compliance issues is makes sense to switch patients from methadone to bupe (particularly if planning to eventually switch the patient to an injectable form of bupe, or if transportation to a methadone clinic is an insurmountable challenge).
  • In the promotion of buprenorphine (which is also an outstanding medication) sometimes methadone incorrectly gets labeled as a problematic, inferior medication, and providers seek to transition patients from methadone to bupe, even though methadone is a more appropriate medication for many patients.
  • Thus, however, if the transition from methadone to bupe must proceed, from my experience I would note the following:
    • Consistent with common guidelines, the patient must achieve a state of moderate opioid withdrawal (e.g. a COWS of at least 13), before administering bupe, to avoid incurring buprenorphine precipitated withdrawal (BPW). [I have made this mistake, and have incurred substantial misery, which can last a day or more.]
    • The decision to rapidly titrate the dose downward first, vs. abruptly stopping the methadone, should be a shared decision with the patient, addressing the need for a sense of control. An example of rapidly titrating down would be dropping from 100mg of methadone daily, and dropping to 60mg on day 1, then 30mg on day 2, and 0mg on day 3, then assessing a COWS on days 4 and 5, and then dosing when moderate withdrawal is achieved. Some patients feel as sense of greater control with this type of taper. However, while some patients find this step-wise drop comforting, others find this painfully prolongs the withdrawal.
    • Plan the stop date and set realistic expectations of duration of withdrawal symptoms. Coordinate around the patient’s schedule, and the patient’s desire to withdraw either during the week, or on the weekend.
  • The primary goal is to prevent relapse during the withdrawal period, and secondarily to not prolong the withdrawal period unnecessarily.
    • Prescribe anti-emetics, and other symptomatic relief medications if possible.
  • Some protocols (particularly if involving higher risk patients – e.g. pregnant patients) even include using short half-life immediate release opioids or fentanyl transdermal patches.
  • Some patients may require a brief hospital stay to avoid a relapse during the transition (if that is an available option).
    • Plan an appropriate dose of buprenorphine to match the patient’s opioid use history and methadone dosing, to adequately relieve withdrawal.
    • Regardless of the patient’s current methadone dose (whether that is 15mg or 200mg), patients stable on methadone are going to withdraw during abstinence (and some will supplement with heroin or other short acting opioids).
  • Get to a COWS of at least 13, then administer bupe.
    • Gradually weaning down the patient’s methadone dose over many weeks (e.g. by 1-3%/week), working towards an opioid free sobriety is not applicable to this discussion.

Developing a Behavioral Treatment Protocol in Conjunction with MAT

Kenneth M. Carpenter, Ph.D, and Nicole Kosanke, Ph.D. – March 26, 2018

Note: This small group discussion is based on the module, “Developing a Behavioral Treatment Protocol in Conjunction with MAT”.

Can the same provider implement both a behavioral treatment protocol and MAT at the same time?

Yes. The four components of a behavioral protocol (skill building and practice, introducing alternative reinforcers, having clinical conversations in an Motivational Interviewing style, and building social supports), can be implemented by the same treatment provider and within the same treatment context that a MAT protocol is being utilized. For example, a Motivational Interviewing stance (and conversational strategies) can be utilized in conversations about medication adherence and address ambivalence a patient may have about their behavioral change plans. In addition, it can be useful to check-in with patients about high-risk situations they may come into contact with between appointments and spend some moments problem solving about ways to handle these situations. In addition, discussing strategies for coping with cravings and urges can be a helpful conversation. It can be also useful to ask patients to outline and record their goals in between sessions and checking back in with them at the next appointment.

Should patients in MAT treatment be required to participate in behavioral health treatment?

There is evidence to suggest utility in adding a psychosocial intervention in conjunction with MAT. However, the specific structure of the behavioral treatment plan can look different. Many controlled studies of Buprenorphine maintenance include structured and weekly Medication Management sessions that can explicitly discuss issues around adherence and addressing barriers to adhering to a change plan. Structured medication management protocols are rarely utilized in many medical settings, although can be an active component in the change process. Further, other factors such as high levels of opiate use at the time of seeking treatment, polydrug use, psychiatric distress, and continued opiate use in the context of MAT over time may be important indicators that augmenting MAT with a behavioral treatment platform would be beneficial to the patient. From a motivational standpoint, requiring participation in a behavioral health protocol should not serve as a barrier to initiating a MAT protocol. Addressing a patient’s ambivalence around a behavioral treatment component could be a topic to address within a regularly scheduled, structured medication management sessions with the goal of having a patient decide that the benefits of having more support and a skills oriented component can outweigh the cons.

How can patients with limited social support be assisted in a MAT framework?

Evidence suggests that including family members in the treatment process confers a better prognosis. This involvement has included family members just attending 1 or 2 counseling sessions to discuss the concerns they may have and ways they can support the patient’s change plan. It can also involve family members attending CRAFT sessions to learn a range of skills and strategies to support the patient’s change process. For patients with limited social support building a supportive structure is critical. Counseling sessions can incorporate elements of a 12-step facilitation protocol to help patient’s connect with a social support system. The SAMSHA website offers links to various peer-to-peer and self-help groups which can be an important component for improving long term outcomes. It is important to discuss the types of peer support groups with the patient and check-in with the patient’s experiences while attending these meetings. The messaging around MAT is not always consistent across groups and patients may receive mixed messages (e.g. MAT is not being in recovery; is not the proper way to change). Thus, regularly checking in with the patient can correct any misinformation and help prepare them with communication strategies to respond to treatment-interfering messages.

Traumatic Brain Injury and Substance Use Disorders

Dr. Jennifer Michaels – April 25, 2017

Is it appropriate to reward people for small successes while in treatment?

There is a long history of using a token economy to reward people for positive behaviors. It’s been practiced successfully for decades. Cash can be problematic as it may be used to purchase illicit substances. Rewards such as gift cards or small gift items have been demonstrated to be very effective in shaping positive behaviors as they mirror the small successes that patients experience in recovery.

Is there a role to get a MRI or PET scan when starting MAT and suspecting TDI?

There is definitely a roll and as a psychiatrist I would work collaboratively with a neurologist to order and interpret results.

Does the buprenorphine dose change for people that have OUD and TDI?

We want to avoid excessive sedation when people have TBI so it’s best to start “low and go slow.” It is also important to avoid other potential CNS depressants. If a patient has co-occurring pain, consider dividing the usual buprenorphine dose into a TID schedule. In general the dose is the same and the goal is the same – to address craving and withdrawal while avoiding any significant side effects.

Outpatient Initiation of Treatment with XR-Naltrexone

Dr. Adam Bisaga – March 21, 2017

How to choose between buprenorphine and naltrexone?

After assessing the appropriateness of the patient for the outpatient treatment the clinician needs to determine which treatment may be most appropriate at that time and engage the patient in a shared decision-making. I would start with evaluating prior treatment history, have they previously tried any of the medication(s), was it effective and well-tolerated? If people were treated in the past with buprenorphine and were successful then that might be your first line of treatment. For those with difficulty adhering to daily buprenorphine, and those that did not stabilize (still had cravings, continued to use on top of the buprenorphine) or were misusing or diverting the medication then you might consider treatment with XR-naltrexone. Alternatively you may try a higher dose of buprenorphine or buprenorphine under supervision. Another issue is the frequency of monitoring, many patients cannot come to the clinic weekly (if necessary), and since XR-naltrexone is given once a month that gives you more flexibility for patients living in a remote areas. Insurance coverage always has to be considered as well. It’s important to explain the differences to the patient so they have a clear understanding of the differences between the medications.

What about the naltrexone patient in need of acute pain treatment while on XR-naltrexone?

Patients tend to overestimate the risk of painful conditions that would necessitate acute treatment with opioids. For acute pain, the anesthesiologist can mange pain well using high-potency opioids or non-opioid strategies. For non-acute pain, blocks work extremely well and should be recommended. For most patients we’ve treated they didn’t need acute opioid analgesia and could wait if they had to have scheduled surgical procedures.

I know that naltrexone can reduce cravings but what is the timeline? I’ve had patients where it doesn’t reduce cravings a great deal.

There have been controlled trials done where patients were unaware if they are receiving active naltrexone or placebos. Within the first week, patients treated with naltrexone reported less craving, even though they did not use opioids so they had no way to tell if they were treated with active naltrexone. We often see patients with very little cravings during the first week after the injection, though they are certainly patients who continue to have cravings, albeit diministed, since they do not experience opioid withdrawal. Not every patient on naltrexone will have reduction of cravings just as not every buprenorphine patient will have reduction of cravings.

How to Deal with Misuse of Non-opioid Substances

Margaret Chaplin, MD – February 16, 2017

How do you approach the counseling aspect of harm reduction?

We use the disease model and approach each separately. For example, if we have a patient with diabetes and asthma, we won’t stop treating the diabetes if they start smoking again and the asthma gets worse. Likewise, we try not to tie buprenorphine treatment to poorly controlled cocaine or alcohol use disorder. The other rationale for the harm reduction approach as opposed to the abstinence model is that the longer someone is in treatment the higher the odds of them getting better. We use motivational interviewing and try to let natural consequences be a platform for discussion. We also use relapse prevention groups and we see people more frequently if they continue to use other substances to try to provide an incentive to decrease use. Often, we will require group 3x weekly along with weekly scripts with the aim of helping them reduce use.

How do you deal with overuse to amphetamines and other substances?

We get a urine test as early as possible since many people don’t expect it the first visit. That helps us understand what substances we need to be concerned about. We will still enroll people with other substance misuse but advise them we will be dealing with their other substance problems and we won’t be able to progress (to monthly scripts for example) if those don’t improve. We get releases from their other physicians. We won’t treat if they won’t let us talk to their physician and we prefer to take over all their psychiatric prescriptions. We also use mouth swabs on occasion as those are harder to alter – not to be punitive but to understand the problem. And we let them know the dangers of combining substances. A huge risk factor for any substance use disorder is untreated ADHD so we do want to treat it, if it is legitimate but we do need to be meticulous with the diagnosis and with ongoing monitoring to make sure that amphetamines are being used therapeutically. We try to document functional improvement with the amphetamines and use the ones with the lowest abuse potential.

Buprenorphine Groups

Ken Saffier, MD and Sara Doorley, MD – May 23, 2016

What do you do with patients who are doing well on buprenorphine as far as abstinence from opioids but still abusing other substances, primarily cocaine and alcohol?

We have a recovery based model but we also embrace harm reduction. One good thing about motivational interviewing is that we can work with them to become less harm reductive and more recovery based. If it interferes with the group process we see them individually. We indicate that patients need to be “present” in the group setting. If they cannot be present then we refer them to individual treatment.

What would consider is the minimum number of patients to have a buprenorphine group?

Some of the best groups I’ve had have been three. Optimal group size is probably 6-8 and maximum would be 10 in terms of dynamics. Small groups allow for more time with each individual and going above 10 can be problematic in that regard. However if the group is too small it can seem overwhelming to the patients to be outnumbered by the team members.

Regarding privacy concerns, do you ask patients to sign a waiver when participating in a MAT group discussion?

Patients sign a Group Consent Form as well as a Consent Form for Treatment. The Group Consent Form explains the treatment in a group setting. With concern about federal confidentiality regulations, it’s important to have your forms vetted by someone knowledgeable of the law to ensure that you are adhering to these regulations.

Opioid Agonist Therapy Clinical Issues

Ed Salsitz, MD – November 19, 2015

I have a patient who is doing very well on buprenorphine but needs to have hernia surgery. What would you do with his medication in the perioperative period?

In general for more minor surgical procedures such as dental work and ambulatory surgical procedures I would continue the buprenorphine and compliment with acetaminophen and NSAIDs. If the buprenorphine dose is low I would increase temporarily as needed. For patients who need major surgery, I would discuss their pain management prior to the surgery. If they are concerned about pain, I would taper them off buprenorphine (not completely), use the full agonist for pain and afterwards return them to their full dose of buprenorphine.

What is your opinion about using tramadol for withdrawal management of opioid use disorder?

My opinion is that it is illegal. The Drug Treatment Act of 1972 and the DATA 2000 makes it clear that there are two medications that are currently approved by the FDA for the maintenance and withdrawal management of opioid use disorder. The first is methadone which has been in use for the past fifty years. The other drug that can be used is the sublingual formulations of buprenorphine. The use of any other opioid product to treat opioid use disorder doesn’t meet the criteria and is therefore not allowed.

How to Select and Use the Most Appropriate Dose of Buprenorphine

Carol Weiss, MD – October 29, 2015

I’ve been told that the patient should not smoke, eat or drink for fifteen minutes prior to taking the buprenorphine dose. They should not talk while taking the dose and there should be no smoking, eating or drinking for fifteen minutes afterwards. Is that important?

Somewhat yes. I think that’s more extensive than the actual guidelines. Fifteen minutes is a bit much. I would say five minutes beforehand. If their mouth is dry they can swish and spit just so there is some moisture. There is no talking while it’s dissolving which can take 5-10 minutes. And then I would wait five minutes afterwards before eating and drinking. However I think fifteen minutes is too much to ask in terms of what people can tolerate.

What percentage of patients in a practice need more than 16 mgs? I’m getting some mildly negative feedback about the number of patients I have on 20-24 mg.

The vast majority of patients that come to me from another provider are on 24 mg of buprenorphine. There are many non-pharmacologic reasons for this: physicians read that it is the maximum dose, they feel it is the safest dose, it’s what the patient wants, etc. If they are stable on that dose, it’s usual pretty easy to get them down to 16 mg. I like to get them down to 16 so there is some wiggle room if I need to increase for pain management.

Managing Buprenorphine Patients: The Basics

Michael Shore, MD – September 17, 2015

How do you feel about people continuing to use alcohol or marijuana when entering treatment for opioids?

It is generally problematic to continue to use marijuana or abuse alcohol when beginning treatment for an opiate use disorder. From the harm reduction perspective, I have a degree of tolerance because for many patients who are in a dangerous situation with opioids having them enter treatment for opioids could be life or death while using marijuana is not a life threatening drug. However if patients are completely unwilling to discuss their particular use of alcohol and marijuana and consider changes, this is a red flag which suggests that more intensive treatment approach will be necessary.

Do all patients need tests for liver enzymes and hepatitis B & C to begin treatment?

No we don’t have to have those things to start treatment. For patients in dire situations, having them delay treatment to first get the lab work done would possibly lose the patient to their continued opiate abuse. Product literature says that getting liver enzymes is recommended. Is it essential? No. Some patients don’t have the money for these additional tests and trying to get these tests done would be problematic.

Do you require the patient to have driver to drive back home after induction day #1 and/or #2?

When someone is coming in for an induction, the assumption is that they are coming in with significant withdrawal. I don’t think they should be driving to the office if they’re that sick. So they’re at risk for that reason alone. People generally feel better by the 2nd or 3rd dose, but not everybody has the same reaction. Some people get energized from buprenorphine, some get sedated. So I think that it is a wise decision when you are giving an induction to require that they have someone drive them to and from the clinic.

When and How to Taper Patients Off Buprenorphine

Joseph Blustein, MD – September 2, 2015

What percentage of your patients are you able to completely wean off buprenorphine?

The rule of thumb is that you’ll be able to wean 80% of patients off of buprenorphine after one year without too much difficulty. Of the remaining 20%, some(~10%) you will be able to wean off with more difficulty, i.e. requiring adjuvant medications, and some (~10%) you will not be able to wean off completely. Over the years, those “unweanable” patients will fill your buprenorphine slots.

Can you elaborate on some adjuvant medications?

I consider these based on the symptoms. I look at their patient/family history to see what has worked for them in the past. As an example, I may use mirtazepine for anxiety and sleep. It has a good sedating effect and if the patient has underlying anxiety it can to help. I may use clonidine if there are withdrawal symptoms. If they are on clonidine for over a week you should not discontinue abruptly but rather do a gradual taper mainly to avoid rebound increase in blood pressure.

Offering Naltrexone to Patients Struggling with Buprenorphine

Adam Bisaga, MD – July 14, 2015

Do we start oral naltrexone before injectable naltrexone?

Package insert for injectable naltrexone does not specify that you need to have a trial of oral naltrexone before the injection. If the patient has a sufficient duration of abstinence from opioids (of 7-10 days) the injection can be safely given. You should carry out urine toxicology test (for morphine, oxycodone, methadone, and buprenorphine) on site right before the injection to confirm that patients did not use any opioids. Please remember that not all opioids would be detected with the rapid test so patients need to be asked about any medications taken in the previous week, to make sure they did not take opioids, and warned of the risk of precipitated withdrawal if naltrexone is given to a person taking opioids. A naloxone test can be conducted by giving 0.8-1.2 mg im and monitoring response over the next 30-45 min. If the test is negative (no change how patient feels- no withdrawal signs/symptoms on COWS scale) then it is very unlikely that withdrawal will be precipitated with injection naltrexone. However if you cannot guarantee the abstinence, and naloxone is not available then you should introduce oral naltrexone at low dose, like 12.5 mg (1/4 of the tablet) or less, at first and if no withdrawal emerges then injection can be safely given (same day few hours later or the next day. 25 mg of oral naltrexone (1/2 of the tablet) is probably too much and may precipitate severe withdrawal as the blood level is comparable to the level after the injection. It is very important to minimize the risk of withdrawal/side-effects with oral formulation since patients that have an adverse experience at the first contact with the medication might be dissuaded from continuing with it as an injection.
Giving small doses of oral naltrexone at first is necessary, but it is a barrier since naltrexone is not commercially available in smaller doses. You can always order low dose oral from a compounding pharmacy in order to get the dose to use for oral induction.

The injectable naltrexone is usually better tolerated than comparable oral doses. There’s less GI distress and nausea, possibly because much lower doses are needed as parenteral formulation bypasses the first-pass metabolism. Bioavailability of injection naltrexone is approximately 4 times greater than bioavailability of oral formulation.

How well does the antagonist work compared to buprenorphine? It seems counter-intuitive that antagonist would have similar effect as an agonist.

Demo Content

How to transition patients treated with buprenorphine that wants to try injection naltrexone. How long after the last does should we wait and how small should the dose be?

Naltrexone is an excellent option for patients who would like to discontinue treatment buprenorphine, but would like to be protected against relapse, which is seen with high frequency during the first few months after stopping buprenorphine.

Buprenorphine is best tapered down to low dose before stopping it, to reduce the level of physiological dependence and to decrease time required for elimination. Usually taper to 2 mg is sufficient, most patients find it difficult to stabilize on lower doses. Alternatively one can use adjunctive medications to minimize symptoms of withdrawal. Adjunctive medications targeting emerging symptoms are also very useful during the washout period and during initiation of treatment with oral naltrexone. Washout period of 4-6 days is usually sufficient after which naltrexone can be started, first at the low oral dose (6-12mg) followed by an injection of XR-naltrexone. With the longer washout there is less risk of withdrawal following injection but higher risk of relapse. Adjunctive medications can be continued during the first 1-2 weeks following injections (see Sigmon, Bisaga et al., 2012 for the list of medications and doses). During this transition patients need to be supported, as it is an outpatient detoxification, preferably with daily medical checkup (in person or on the phone) and psychosocial support if available.

Opioid Agonist Therapy Clinical Issues

Ed Salsitz, MD – May 13, 2015

Is there a maximum dose of methadone for pain management allowed by the DEA?

I don’t believe there is a maximum dose of methadone. You may have to get permission from the state opioid treatment authority for certain amounts. The largest dose I’ve seen is 1400mg a day. The patient was functioning well and it helped his pain. Most of overdose deaths with methadone occur in the pain sector. Methadone can be very tricky and careful monitoring is necessary.

How do you deal with patients who are in a detox program with their first abnormal drug screen while undergoing gradual taper?

It can take a while for urine tests to become negative. People have been suffering for many years so you can’t expect this problem to go away after a few treatments. Maybe it’s an indication that the patient should be placed on maintenance rather than tapering.

Patient is on a stable dose subxone but reports suboxone no longer holds him. Can tolerance develop to opioid agonist effect?

Yes but not as much as when people are on chronic opiates for pain. The methadone experience has been remarkable – people who are doing well on methadone seem to be able to stay on the same dose of methadone for years. People have ascribed that to the fact that methadone is an opioid agonist but that it also has NMDA(a glutamate receptor) antagonist effects, and this may moderate the development of tolerance.

We have less experience with buprenorphine but my own experience is that people generally don’t require an increase in dose and will often go down in dose to see what happens. If they still feel good they’ll usually stay at that new dose. Generally tolerance does not create a problem for opioid agonist therapy.

Buprenorphine Treatment to Patients with Co-Occurring Non-Cancer Pain

Matt Tierney, RN, MS, NP – January 22, 2015

38 year old male with severe nerve damage. He had a loss of functioning after an overdose. He’s been sober 6 months with good pain relief while on buprenorphine. He’s on 16 mg dose TID (3 times a day) and he’s requested to go up.

QID Dosing (4 times a day) is sometimes beneficial for patients with chronic pain. I had a patient with neuropathic pain and chronic headaches. Had her on 8 mg TID but we switched her to 4 QID she had an improved benefit. The total daily dose was lower but the dosing schedule change seemed to provide additional analgesic benefit.

There are some who think that if you’re going to treat the person for pain, it should be done in an internal medicine clinician’s office rather than a psychiatrist’s office. Do you give different recommendations to psychiatrists vs internal medicine on these issues?

In our practice all of our patients have some history of addiction. My view is that those co-occurring problems are so intertwined that you’re always treating both problems. Any decrease in pain or distress decreases the chance for relapse so you’re still treating the addiction. So any time you’re adjusting the buprenorphine dose for analgesic benefit you should consider the benefit or risk to the relapse prevention as well.

Aberrant Behavior

Peter Friedmann, MD – November 18, 2014

Patient has been in program for several years. He has used drugs since he was a teenager. No long period of sobriety in his life. After two recent overdoses, they said they were going to taper his methadone. He went into detox where they maintained his methadone dose. He decided to try a residential treatment. How do you reach patient in the late stage of their addiction?

This is a challenging patient, “late in their addiction career.” These are often the difficult questions as these are often the sickest patients. The options will be limited with a late stage case like this. Methadone doesn’t treat benzodiazepine or cocaine dependence so you’ll need other strategies, including medication, to treat these other disorders.

Discussing naloxone and overdose prevention with family is sometimes a good mechanism for expressing your concern about how he is doing. It’s a good message with which to reach him.

Why should you not refer to testing samples as “clean” or “dirty.”

I prefer to refer to the sample as either positive or negative. As professionals managing patients in a medical context we should avoid street slang when discussing these as it stigmatizes the disease.

Physicians underutilize the tools at their disposal with regard to monitoring patients and their sobriety.

Monitoring routinely conveys an expectation. If you only monitor when you suspect something, it may stigmatize the monitoring. Watching people take the medication can be important to ensure they are taking it the right way, as it testing them afterwards to determine a baseline for their levels. Pill counting is another important tool at your disposal. By establishing an expectation of monitoring, people tend to be more honest in their self reports. It should be a normal part of what you do with all patients.

How do you address problem behaviors?

The less people adhere to a program, the more structure they need. That means seeing them more often, more frequent monitoring and perhaps intensifying treatment. I believe monthly prescriptions are a privilege and if they need to earn that privilege by doing well. It’s important to document our actions very clearly because that’s what protects us and protects our patients.

Treatment of Opioid Use Disorder in Veterans

Ayman Fareed, MD – October 29, 2014

When covering for another MD, is it legal to continue the prescription without seeing the patient?

If it’s for an emergency then you can do it. For example If a patient is suicidal or was admitted to the psychiatric floor for another reason other than drug addiction, and the patient is being maintained on buprenorphine, then any physician even if does not have the waiver to prescribe buprenorphine can continue the prescription to avoid the withdrawal. If you can see the patient that would be a better option but if it’s an emergency and the patient is at risk of relapse then at least perhaps speak with the patient on the phone and document that and give the patient a few days until the primary provider comes back. The good thing about buprenorphine is that it is Schedule III so you can order it over the phone which is good for cross-coverage issues.

Do you pill count? Do you treat younger patients differently from older patients with opioid addiction?

We treat all ages in our clinic. For younger veterans we get a good history and prefer to start them on buprenorphine maintenance. We have a treatment agreement which covers the rules of the clinic including a call back policy. The nurse calls them and they must return to the clinic within 24 hours with their buprenorphine pills. We take urine checks and do pill counts. We check their buprenorphine and norbuprenorphine levels to make sure they are taking it and not selling it. We do this randomly.

During the induction phase they have to come a few days in a row. Then weekly. We don’t give more than a week’s prescription at a time. After the first month we can decide if they need more intensive treatment or not.

We have contracted with an outside contracted clinic whose main goal is to get people off suboxone. I’ve found that they’re very likely to relapse when the attempt is made. What’s your experience with getting people off suboxone permanently?

I have the same experience. It’s supported by the literature – a study showed that at the maintenance level relapse was about at 10% whereas at the taper it was 50%. It’s my clinical experience as well. I tell people that it’s their choice and I can’t force them to stay on suboxone but if they relapse it’s okay, they can come back in and we’ll start them again.

When collecting a urine sample, unless you get at least 15 ccs of urine it’s hard to test for anything. Also when doing a buprenorphine screening and assessment, that takes a few days to come back. If a patient is selling suboxone and takes a pill before coming in for the screening, will you be able to tell that?

We rely on the norbuprenorphine to buprenorphine ratio. The norbuprenorphine should be double the buprenorphine. If the norbuprenorphine is low and the buprenorphine is high, then the patient may not have been taking it for several days and restarted before coming to the screening.

How do you handle inductions with patients who have severe medical comorbidities?

You don’t want to be the only provider treating these co-morbidities. You’ll want to collaborate with primary care, pain specialists, etc to combat these problems. My role is to determine if the patient meets the criteria for opioid use disorder. If not then I would refer them to another provider since it is not my area of expertise.