Fatal and non-fatal drug overdoses are an ongoing national epidemic. As we confront the evolving nature of the overdose epidemic it has become apparent that prescription opioids are not the only contributor Illicitly manufactured fentanyl and fentanyl analogs are now the primary drivers of the epidemic of opioid use and opioid related overdose. CDC data reported approximately 72,000 overdose deaths nationally in 2019 followed by an increase at the end of 2020 to just over 90,000. We must do better. Missouri is working hard to address the epidemic. This physician toolkit, presented by the Missouri State Medical Association (MSMA) and the American Medical Association (AMA) provides state and national resources and tools for Missouri physicians to use to help address overdose prevention, substance use and substance use disorder, harm reduction, safe opioid prescribing and management, and provide better care for pain.